I produce work in Pixarra's Twisted Brush painting program where the digital pixels appear to have been painted onto the digital canvas.
I also work in Photoshop CS5.
This work may be used on monitors and may be printed out also. My 16 to 9 ratio work will work well on large monitors and television monitors as art work. Much of my work is in high resolution and will appear to have much more detail when viewed as the large original.